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It was during Lucky Luciano 's organization of the American Mafia after the Castellammarese War , following the assassinations of "Joe the Boss" Masseria and Salvatore Maranzano , that the gang run by Joseph Profaci became recognized as the Profaci crime family. The family traces its roots to a bootlegging gang formed by Profaci in Profaci would rule his family without interruption or challenge until the late s.
The first war took place during the late s, when caporegime Joe Gallo revolted against Profaci, but that conflict lost momentum in the early s when Gallo was arrested and Profaci died of cancer. The family was reunited in the early s under Joseph Colombo. In , the second family war began after Gallo's release from prison and the shooting of Colombo.
Colombo supporters led by Carmine Persico won the second war after the exiling of the remaining Gallo crew to the Genovese family in The family would then enjoy over 15 years of peace under Persico and his string of acting bosses.
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In , the third and bloodiest war erupted when acting boss Victor Orena tried to seize power from the imprisoned Persico. The family split into factions, loyal to Orena and to Persico, and two years of mayhem ensued. It ended in , with 12 members of the family dead and Orena imprisoned, leaving Persico the winner.